Cytokine Knockouts 2nd ed (Contemporary Immunology) by Giamila Fantuzzi

By Giamila Fantuzzi

Sporting at the excessive criteria of the a lot praised first variation (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of specialists have generated thoroughly new chapters to mirror using many novel mouse lines and the loads of contemporary reports on cytokine body structure. complete studies of the various often-surprising effects got utilizing cytokine knockout mice are supplied, in addition to a lot vital information regarding cytokine biology and body structure. For these now not conversant in cytokine examine, the authors current a serious dialogue of the benefits and drawbacks of utilizing cytokine knockout mice in quite a few fields of analysis.

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Mol. Med. 3, 864–875. 25. Koniaris, L. , and Wright, T. M. (2001) TNF mediates a murine model of Addison’s crisis. Shock 15, 29–34. 26. , et al. (1993) Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364, 798–802. 10 Ghezzi 27. , and Lesslauer, W. (1994) Phenotypic analysis of TNFR1-deficient mice and characterization of TNFR1-deficient fibroblasts in vitro. Circ. Shock 44, 51–56. 28.

Tuberculosis (75). In studies using either neutralizing anti-TNF-α antibodies or TNF-RI knockout mice, there was a decrease in NO from macrophages early in the infection that was thought to contribute to decreased host resistance (75). TNF-α deficient mice have been injected intravenously with either the Kurono strain of human M. tuberculosis or BCG. The Kurono strain is lethal in the TNF-α-deficient mice compared with wild-type mice, with 80% dead after 50 d compared with no deaths in wildtype mice (76).

1998) Stem cell factor-deficient mice have a dysregulation of cytokine production during local inflammation. Eur. Cytokine Netw. 9, 85–92. 37. Leon, L. , and Kluger, M. J. (1997) Exacerbated febrile responses to LPS, but not turpentine, in TNF double receptor-knockout mice. Am. J. Physiol. 272, R563–R569. 38. , et al. (1994) Defective inflammatory response in interleukin 6-deficient mice. J. Exp. Med. 180, 1243–1250. 39. , et al. (1997) Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

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