Ciba Foundation Symposium 191 - Non-Reproductive Actions of

Well-known clinicians and researchers from different disciplines speak about the elemental phone and molecular biology of steroid motion and intercourse steroids' results at the fearful and immune platforms. offers an built-in review of the benefits and downsides of hormone alternative treatment.

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Liaison spkcifique de I’oestradiol a des protkines utkrines. C R Acad Sci Ser 111 Sci Vie 265:354-357 34 Baulieu & Robel Baulieu EE 1978 Cell membrane, a target for steroid hormones. Mol Cell Endocrinol 12247-254 Baulieu EE, Godeau F, Schorderet M, Schorderet-Slatkine S 1978 Steroid-induced meiotic division in Xenopus luevis oocytes: surface and calcium. Nature 275: 593-598 Baulieu EE, Schorderet-Slatkine S 1983 Steroid and peptide control mechanisms in membrane of Xenopus luevis oocytes resuming meiotic division.

However, our present knowledge of chromatin structural diversity, related to DNA base sequences, bending and associated proteins, leaves the way open for specific functional steroid-DNA interactions. They would occur only under defined conditions when steroids have direct access to DNA. In spite of some early work (Liao et al 1989), there is no definitive demonstration of primary post-transcriptional function of steroid receptors. Nevertheless, steroid hormones often modify post-transcriptional events, such as mRNA stability and efficiency of translation, or provoke post-translational modifications of proteins.

For instance, oestrogen metabolites may have distinct, even opposing, biological effects. Do you have any evidence that different forms of the oestrogen response element may have a role in this respect? Beato: The different hormone-responsive elements respond differently-this has been shown experimentally. If a different hormone-responsive element has 42 Discussion a high affinity for the receptor, you need less receptor or less hormone to generate induction. Some of the elements are supposed to act as negative elements (this idea has been mainly put forward by Keith Yamamoto) that do not induce the same type of conformational change in the receptor as is seen with the positive binding sites.

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