By Frank Entschladen, Kurt S. Zanker
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Additional resources for Cell Migration: Signalling and Mechanisms (Translational Research in Biomedicine, Vol. 2)
Arthritis Res Ther 2007;9:R28. 48 Petrilli V, Dostert C, Muruve DA, Tschopp J: The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 2007;19: 615–622. 49 Church LD, Cook GP, McDermott MF: Primer: inflammasomes and interleukin-1β in inflammatory disorders. Nat Clin Pract Rheumatol 2008;4:34– 42. 50 Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, Mackenzie A, Maltais LJ, Nunez G, Ogura Y, Otten LA, Philpott D, Reed JC, Reith W, Schreiber S, Steimle V, Ward PA: The NLR gene family: a standard nomenclature.
Leukocyte transmigration and recruitment to tissues are severely impaired in patients with leukocyte adhesion deficiency , implicating an essential role for β2 integrins in neutrophil function. Signaling molecules downstream of integrins and receptor activation have also been implicated in immunodeficiency disorders. For example, Rac2 is a hematopoietic-specific family member that has been shown to be crucial for proper neutrophil chemotaxis into inflamed tissue . A patient with a dominant mutation in Rac2, D57N, has been reported who presented with recurrent bacterial infections and impaired neutrophil polarization and chemotaxis , indicating an essential role for Rac2 in neutrophil-directed migration and highlighting the role of migration in immunodeficiencies.
57 Huttenlocher A, Frieden IJ, Emery H: Neonatal onset multisystem inflammatory disease. J Rheumatol 1995;22:1171–1173. 58 Goldfinger SE: Colchicine for familial Mediterranean fever. N Engl J Med 1972;287:1302. 59 Dinarello CA, Wolff SM, Goldfinger SE, Dale DC, Alling DW: Colchicine therapy for familial mediterranean fever. A double-blind trial. N Engl J Med 1974;291:934–937. 60 Cooper KM, Bennin DA, Huttenlocher A: The PCH family member PSTPIP1 targets to the leukocyte uropod and regulates directed cell migration.