Anti-vegf (Developments in Ophthalmology) by F. Bandello, M. Battaglia Parodi, A.J. Augustin, P. Iacono,

By F. Bandello, M. Battaglia Parodi, A.J. Augustin, P. Iacono, R.O. Schlingemann, U. Schmidt-Erfurth, F.D. Verbraak

The improvement of remedy with anti-angiogenics or vascular endothelial progress issue inhibitors (anti-VEGF) has marked the start of a brand new period in neovascularization and macular edema remedy. Its major ambitions are the inhibition of development and improvement of latest vessels besides the aid of vascular permeability. the benefits over traditional laser photocoagulation are obtrusive as laser therapy constantly leaves scars and motives a retinal sensitivity deterioration. beginning with an summary of remedy ideas, this quantity covers all points of anti-VEGF treatment for ophthalmological issues. particularly, particular chapters are devoted to age-related macular degeneration, degenerative myopia, angioid streaks, inflammatory illnesses, hereditary dystrophies, retinal vein occlusion, diabetic retinopathy, ocular tumors, in addition to anterior phase neovascularization. The e-book offers an replace at the program of anti-VEGF in ocular ailments to normal ophthalmologists in addition to retina experts.

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Opt Express 2009;17:4037–4045. Anti-VEGF in Age-Related Macular Degeneration 79 Ahlers C, Gotzinger E, Pircher M, et al: Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography. Invest Ophthalmol Vis Sci 2010;51:2149–2157. 80 Puliafito CA, Hee MR, Lin CP, et al: Imaging of macular diseases with optical coherence tomography. Ophthalmology 1995;102:217–229. 81 Pieroni CG, Witkin AJ, Ko TH, et al: Ultrahigh resolution optical coherence tomography in non-exudative age-related macular degeneration.

32 Adding a humanized antibody to vascular endothelial growth factor (bevacizumab, Avastin) to chemotherapy improves survival in metastatic colorectal cancer. Clin Colorectal Cancer 2003;3:85–88. 33 Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al: Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003;21:60–65. 34 Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.

98 Chan CKM, Meyer CHM, et al: Retinal pigment epithelial tears after intravitreal bevacizumab injection for neovascular age-related macular degeneration. Retina 2007;27:541–551. 99 Apte RS: Retinal pigment epithelial tear after intravitreal ranibizumab for subfoveal CNV secondary to AMD. Int Ophthalmol 2007;27:59–61. Prof. at 38 Schmidt-Erfurth · Pollreisz · Mitsch · Bolz Bandello F, Battaglia Parodi M (eds): Anti-VEGF. Dev Ophthalmol. B. Bietti per l’Oftalmologia, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Rome, and bDepartment of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy Abstract Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) represent the most common causes of vision loss in patients affected by diabetes mellitus.

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