Anaerobic infections in humans by Sydney M. Finegold, W. Lance George

By Sydney M. Finegold, W. Lance George

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Med. 26, 119-138. Bullock, W. , and Cramer, W. (1919). On the mechanism of bacterial infection, with special reference to gas gangrene. Sei. Rep. Imp. Cancer Res. Fund, 6th 23-69. Burke, G. S. (1919). Notes on Bacillus botulinus. J. Bacteriol 4, 555-565. Carle and Rattone (1884). Studio sperimentale sull eziologia del Tetano. J. Acad. Med. Turin 32, 174. Chalian, W. (1940). An essay on the history of lockjaw. Bull. Hist. Med. 8, 171-201. , and Arloing, S. (1884). Etude expérimentale sur la septicémie gangreneuse.

A s medicine m o v e d into the antibiotic era, early studies on the antimicrobial sensitivities of fusobacteria and bacteroides set the pattern of prescribing practice that w a s to successfully span the period of the " a n a e r o b e r e n a i s s a n c e " of the 1960s. Fusobacterium necrophorum was susceptible to penicillin, chloramphenicol, and tetracyclines; Bacteroides spp. derived from intraabdominal sepsis w e r e usually resistant to penicillin, but sensitive to tetracyclines, chloramphenicol, and erythromycin.

Temperature after four oxygen sessions was 37°C. The patient was cured after seven oxygen sessions in the course of three days, and the leg was completely saved. Surgery, for so long the primary and radical ingredient of an often mutilating t r e a t m e n t , w a s thus relegated to a supportive, s e c o n d a r y , and c o n s e r v a t i v e role. III. Nonclostridial Anaerobic Infections " T h e r e are m o r e animals in the uncleaned matter on the teeth in o n e ' s m o u t h t h a n t h e r e are m e n in the whole kingdom, especially in those w h o n e v e r clean their m o u t h s , owing to which such a stench c o m e s from the m o u t h of m a n y that o n e can hardly b e a r talking to t h e m .

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