By Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)
During the last 10 years, paintings on acute promyelocytic leukemia (APL) has turn into the paradigm of translational learn that begun with the invention of a recurrent chromosomal translocation, through the id of the genes and proteins concerned, discovering their molecular capabilities in transcriptional regulate, setting up mouse types and culminating within the improvement of distinctive treatment.
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Extra info for Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313)
He L, Bhaumik M, Tribioli C, Rego EM, Ivins S, Zelent A, Pandolﬁ PP (2000) Two critical hits for promyelocytic leukemia. Mol Cell 6:1131–1141 29. He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolﬁ PP (1998) Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nat Genet 18:126–135 30. Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD (1999) A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF.
Mol Endocrinol 12:1161–1171 33. Reference deleted in proof 34. Hyman J, Chen H, Di Fiore PP, De Camilli P, Brunger AT (2000) Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ ﬁnger protein (PLZF). J Cell Biol 149:537–546 35. Ikeda R, Yoshida K, Tsukahara S, Sakamoto Y, Tanaka H, Furukawa K, Inoue I (2005) The promyelotic leukemia zinc ﬁnger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1.
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